ISSN: 2157-7013
Faculty of Medicine, Department of Human Anatomy and Embryology, Suez Canal University, Egypt
Dr. Shimaa Anter Fareed
Human Anatomy and Embryology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Subjects of Specialization: Morphometry, Occipital Condyles, Histopathology, Ultra-structure.Jejunal mucosa
Research Article
Rat Bone Marrow-Derived Mononuclear Cells Outperform Folic Acid in the Treatment of Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats
Author(s): Manal H Al-Badawi*, Shimaa Anter Fareed and Mona Hassan Mohamed
Background: Diabetes mellitus is the most common cause of peripheral neuropathy, which itself is mediated in part via oxidative stress. Recent studies have used stem-cell-based therapies to regenerate nerve tissues following diabetic neuropathy. Folic acid supplementation promotes neuronal development and protection in some neurological diseases.
Aim: This study aims to compare the effects of bone marrow-mononuclear cells (BM-MNCs) and folic acid (FA) in the treatment of peripheral neuropathy in streptozotocin-induced diabetic rats.
Methods: Forty adult male albino rats were randomly divided into five groups: Group I (healthy control group); Group II, diabetic group (a single intraperitoneal streptozotocin injection); Group III, diabetic rats that received BM-MNCs; Group IV, diabetic rats that were treated with FA .. View More»
DOI:
10.35248/2157-7013.19.10.291