ISSN: 2157-7013
Faculty of Medicine, Department of Human Anatomy and Embryology, Helwan University, Egypt
Manal H Al-Badawi.
Faculty of Medicine, Department of Human Anatomy and Embryology, Helwan University, Egypt.
lecturer of anatomy, Suez canal university.
Subjects of Specialization: Cell Science, Apoptosis, Liver Regeneration, stem cells, Mitochondria.
Research Article
Rat Bone Marrow-Derived Mononuclear Cells Outperform Folic Acid in the Treatment of Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats
Author(s): Manal H Al-Badawi*, Shimaa Anter Fareed and Mona Hassan Mohamed
Background: Diabetes mellitus is the most common cause of peripheral neuropathy, which itself is mediated in part via oxidative stress. Recent studies have used stem-cell-based therapies to regenerate nerve tissues following diabetic neuropathy. Folic acid supplementation promotes neuronal development and protection in some neurological diseases.
Aim: This study aims to compare the effects of bone marrow-mononuclear cells (BM-MNCs) and folic acid (FA) in the treatment of peripheral neuropathy in streptozotocin-induced diabetic rats.
Methods: Forty adult male albino rats were randomly divided into five groups: Group I (healthy control group); Group II, diabetic group (a single intraperitoneal streptozotocin injection); Group III, diabetic rats that received BM-MNCs; Group IV, diabetic rats that were treated with FA .. View More»
DOI:
10.35248/2157-7013.19.10.291