Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Department of Research and Development, Zeon Lifescience LTD, Rampur Ghat Road, Village Kunja, Paonta Sahib, Himachal Pradesh, India
Research Article
Evaluation Acute Toxicity Studies of Hydro Alcoholic Extract of Soursop Leaves (Annona muricata) on Brain, Liver and Kidney of Wister Rats
Author(s): Shalu Chauhan* and Vivek Srivastava
Objectives: The present study was undertaken to evaluate the acute oral toxicity of hydro-alcoholic leave extract of Annona muricata and to derive the LD50. The purpose of the study was to investigate acute toxicity test of soursop leave extract on Wister rat brain, liver and kidney.
Methods: Acute toxicity studies of hydro alcoholic leave extract of Annona muricata were conducted as per the OECD guidelines 407. The animals were grouped into three test and one control groups. Except for treatment with the test substance, animals in the control group were Liaw led in an identical manner to the test group subjects. The mice were observed until day 7 to determine the LD50 and at the end were terminated to collect the brain, liver and kidney. The organs later were made into histopathology slides. The slide.. View More»
DOI:
10.35248/2161-0495.24.14.556