Endocrinology & Metabolic Syndrome
Open Access

Department of Hematology, Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China

Publications

• Case Report   
  Isolated Adrenocorticotropic Hormone Deficiency Caused by Camrelizumab in a Patient with Lung Sarcoma: A Case Report and Literature Review
  Author(s): Wen Huang and Saran Feng*
  
  Immune checkpoint inhibitors (ICIs) significantly increase survival in some malignant tumors, but they also lead to a variety of immune-related adverse events that affect multiple organs, including the liver, lung and endocrine system. Isolated adrenocorticotropic hormone deficiency (IAD), a rare pituitary disorder, may manifest with non-specific symptoms. Clinicians may not be aware of this unusual side effect. We hereby describe a 70-year-old male patient who had lung sarcoma and was treated with camrelizumab. He developed immune-related pneumonia and hepatitis, subsequent late-onset IAD with severe hyponatremia. His symptoms alleviated after glucocorticoid therapy. So regularly monitoring endocrine functions should be beneficial for cancer patients treated by camrelizumab. Clinicians should consider IAD induced by ICIs when hyponatremia occurs in these patients.. View More»
  DOI: 10.35248/2161-0495-22.12.360

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