Medical & Surgical Urology

Medical & Surgical Urology
Open Access

ISSN: 2168-9857

Santosh Kumar

Department of Urology, PGIMER, Chandigarh, India

  • Research Article   
    Correlation of miR-100 Expression with Clinopathological Parameters in Bladder Cancer
    Author(s): Manjeet Kumar*, Santosh Kumar, Shrawan Kumar Singh, Rajendra Prasad and Aman Kumar

    Objective: Bladder carcinoma is one of the most common tumors in the world and, despite the therapy currently available, most of the patients relapse. MicroRNA- 100 is down regulated in bladder cancer tissue in comparison to normal tissue; however, clinical significance of miR-100 in human bladder cancer has not been elucidated. The aim of study was to correlate miR 100 expression levels with tumor grade, stage and recurrence. Methods: Expression of miR-100 in 26 pairs of bladder cancer and adjacent normal tissues were analysed by Sybergreen RT-PCR. The expression levels of miR 100 in tumor and normal were normalised with 18s gene. The expression levels of miR 100 expression were analysed in fold change (DDCT method). The difference between groups were analysed by student t test and Anova. Results: Downregulation of mi.. Read More»
    DOI: 10.35248/2168-9857.20.9.230

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