Journal of Physical Chemistry & Biophysics
Open Access
ISSN: 2161-0398
ISSN: 2161-0398
Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, Campus Vienna Biocenter 5, 1030, Vienna, Austria
Research Article
Hypothetical Pathways on GlycoRNA Biochemistry
Author(s): Santiago Alonso Gil*
GlycoRNAs are recently discovered biomolecular structures whose medical relevance is key to understanding cellcell communication. Research fields such as immunology and tumor research are developing theories around these novel conjugates located on the cell surface. The work of Bertozzi is a reference where the experiments show relevant physicochemical properties of the sialylated RNA conjugates. Going through the current enzymatic and chemical available data, in this work, we hypothesize on the possible biochemical pathways leading to N-glycosylation of RNA nucleobase. Based on the reactivity of glycoRNA with oligosylsaccharide transferases and the PNGase F hydrolase, we base our hypothesis on the conjugation of modified versions of the canonical nucleobases and the GlcNAc moiety through an amide-functionalized small linker. We assume that every nucleobase (A, C, G, and U) is modifi.. View More»
DOI:
10.35248/2161-0398.23.13.359