Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Department of Emergency Medicine, Rashid Hospital and Trauma Center, Dubai Health, UAE
Case Report
Massive Valproic Acid Overdose with Confirmed Pharmacobezoar Formation and Neuromuscular Toxicity: A Case Report and Literature Review
Author(s): Maryam Alrazooqi*, Lara Abumuaileq, Sania Zia and Sara Nooruddin Kazim
Introduction: We present the case of a 42-year-old male who arrived obtunded to our Emergency Department (ED) following an intentional ingestion of approximately 60 grams of extended-release Valproic Acid (VPA). Subsequent imaging and endoscopy confirmed the presence of a pharmacobezoar, a rare and underreported complication of overdose, and his course was further distinguished by the development of delayed neuromuscular toxicity. Methodology: Clinical, laboratory, imaging, endoscopic and neurophysiologic data were abstracted from the electronic medical record. Case Report: The patient was managed with early airway protection, gastrointestinal decontamination initially with single-dose and later with multiple-dose activated charcoal regimens. He received Intravenous (IV) Levocarnitine (L-carnitine), naloxone and Continuous Renal Replacement Therapy (CRRT). His hospital course was init.. View More»