Journal of Cancer Research and Immuno-Oncology
Open Access
ISSN: 2684-1266
+44-20-4587-4809
ISSN: 2684-1266
+44-20-4587-4809
Department of Clinical Immunology, Medical University of Bialystok, Bialystok, Poland
Research Article
A New Set-Up of Vanishing Antibodies: A Biennial Follow-Up of Five Different Clients' Humoral Responses against SARS-CoV-2 after Systemic Vaccination in an Oncology Hospital in Poland
Author(s): Piotr Kosiorek*, Samuel Stróż, Anna Hryniewicz, Dorota Elżbieta Kazberuk, Robert Milewski, Klaudia Bartoszewicz, Magdalena J oanna Borkowska and Anna Stasiak-Barmuta
The humoral response of the COVID-19 vaccine varies from person to person. It largely depends on prior SARS-
CoV-2 infection, obtaining an adequate immune response, and leaving a trace of changing antibody concentration
over time. We retrospectively analyzed five clinical cases from selected patients and employees of the oncology
hospital. All mild COVID-19 convalescents received the BNT162b2-Comirnaty mRNA vaccine three or four times.
The levels of SARS-CoV-2 IgM- and IgG-specific antibodies, as well as S-RBD antibodies, were analyzed for two years.
The concentration of antibodies was assessed in the laboratory using the chemiluminescent immunoassay CLIA,
MAGLUMI.
Results: (1) Active autoimmune disease stabilized the level of IgG-specific antibodies after systemic mRNA vaccination
for at least six months. (2) Post-vaccination IgG and S-RB.. View More»
DOI:
10.35248/2684-1266.22.8.156