Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
ISSN: 2329-8790
Department of Hematology, University of Liverpool, Liverpool, Tunisia
Mini Review
WNT Proteins in Hematopoiesis: Regulatory Mechanisms Using the QCE6 Mesodermal Stem Cell Line
Author(s): Samantha Parker*
WNT proteins constitute a family of secreted signaling molecules pivotal in orchestrating cell fate and behavior. This study investigated the potential impact of WNTs on hematopoietic cell destiny. Utilizing both Hematopoietic Progenitor Cell (HPC)-enriched embryonic avian bone marrow cells and the quail mesodermal stem cell line QCE6, comparable behaviors were observed under optimized conditions. These cells demonstrated identical differentiation into diverse blood cell types, including Red Blood Cells (RBCs), monocytes, macrophages, granulocytes and thrombocytes. The extensive spectrum of blood cell phenotypes exhibited by QCE6 cells was contingent upon their active expression of WNT11. Conversely, inhibition of WNT11 production in QCE6 cells, achieved through the expression of a stably transfected WNT11 antisense transgene, resulted in cultures dominated by highly vacuolated macrop.. View More»
DOI:
10.35248/2329-8790.25.13.645