Journal of Cancer Research and Immuno-Oncology
Open Access

Department of Cancer Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, India

Publications

• Research Article   
  Non-proliferating Effect of Syzygium cumini and Spondias pinnata Against Colorectal Carcinoma
  Author(s): Yalachigere Kempaiah Suneetha*, Hongasandra Lakshmipathy Neha and S. Anand
  
  Background: In today’s world the use of medicine, especially of plant origin, is acquiring a lot of significance in restorative applications because of the relatively low harmfulness when contrasted with designed pharmaceuticals. Methods: Methanolic extracts of Spondias pinnata, and Syzygium cumini were evaluated for antioxidant properties using DPPH and ABTS radical scavenging assays. MTT assay for the extract was carried out against the HCT116 cell line. HCT1116 cells treated with 40 and 80 μg/mL of S. cumini were studied using Annexin V FITC flow cytometry. PCR analysis of the caspase3 gene in HCT116 cells treated with 40 and 80 μg/mL of S. cumini extract was done to confirm apoptosis. A hemolysis assay was performed to determine the toxicity effect of the plant extracts on human RBCs. .. View More»
  DOI: 10.35248/2684-1266.25.11.237

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