Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Safety Science Research Laboratories, R & D Headquarters, LION Corporation, Tokyo, Japan
Research Article
Evaluation of Skin Sensitization Using Amino Acid Derivative Reactivity AssayOrganic Solvent (ADRA-OS), an Alternative to Animal Tests: Effects of Epoxy
Compound
Author(s): Ryo Koizumi, Hiroaki Yamaga*, Koichiro Hayashi, Shinichi Watanabe and Shinsuke Kataoka
Skin sensitization is classified as a type IV (delayed) allergy (allergic contact dermatitis) caused by T lymphocyte activation that manifests as an inflammatory reaction within 48 hours of contact with a causative allergen. It can directly decrease the quality of life for those who are afflicted. Therefore, to appropriately determine the potential of chemical substances to sensitize skin is extremely important.
The development of alternatives to animal tests according to the Adverse Outcome Pathways (AOPs) of skin sensitization has recently progressed and test guidelines have been established by the Organization for Economic Cooperation and Development (OECD). The potential of chemicals to sensitize skin is difficult to determine using a single test and an alternative method that precisely reflects the results of animal experiments is not available. The coverage of alternat.. View More»
DOI:
10.35248/2161-0495.23.13.541