Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Rubi C Calderón-Meléndez

Department of Immunology, Autonomous University of Nuevo León, Av. Gonzalitos # 235 Col. Mitras Centro, C.P. 64460, Monterrey, Nuevo Leon, Mexico

  • Mini Review   
    Neutrophil and Macrophage Response to Hypoxia in the Context of Inflammatory and Infectious Diseases
    Author(s): Antonio Muñiz-Buenrostro, Mario C Salinas Carmona, Rubi C Calderón-Meléndez and Alma Y Arce-Mendoza*

    Neutrophils and macrophages are the first line of defense against pathogens. They have the ability to eradicate pathogens in an environment with inflammation and hypoxia. How these cells adapt to that environment is something that has been studied for several years now. HIF-1α is the main orchestrator to maintain this cells functional in hypoxia, and more recently is have established that HIF-1α can be stabilized by bacterial antigens in the absence of hypoxia via NF-κB, making HIF-1α a key protein in the innate immune response. Using HIF-1 as a therapeutic target requires knowing the pathogen that is causing the infection and whether this infection is local or systemic. In this review we gathered information about this issue to understand how these cells remain functional in this type of environment where you have a pathogen, inflammation and.. View More»
    DOI: 10.35248/2155-9899.21.12.610

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