Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
ISSN: 2155-9554
Department of Surgical, Medical, Dental, and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy
Review Article
Regulatory Role Played by the mRNA Binding Protein Tristetraprolin in the Skin and its Involvement in Different Diseases
Author(s): Roberta Lotti and Tommaso Zanocco-Marani*
The mRNA binding protein Tristetraprolin (TTP), encoded by the ZFP36 gene, plays a fundamental regulatory role
in a wide variety of cellular processes by means of its widespread expression in different tissues, and of its ability to
post transcriptionally regulate the stability, and therefore the expression, of multiple specific target mRNAs. Because
of these features, TTP expression and activity are strictly regulated, and malfunctions of such mechanisms underlie
different pathologies. Here we recapitulate the role of TTP in the skin, and its involvement in different conditions,
with special reference to psoriasis and cancer... View More»
DOI:
10.35248/2155-9554.21.s10.574