Journal of Genetic Syndromes & Gene Therapy
Open Access

Department of Zoology, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, India

Publications

• Review Article   
  Duchenne Muscular Dystrophy: A Review on Systemic Paradigm Approaching Diagnosis to Therapy
  Author(s): Srabaita Roy*, Ranjit Shaw*, Sukanya Samaddar, Sukanya Samanta, Ritwija Maity, Puja Chatterjee, Ankita Das, Suchismita Bhaumik and Gyaneshwer Chaubey
  
  Duchenne Muscular Dystrophy (DMD) is a severe congenital disorder caused by DMD gene mutations, which results in muscular degeneration and movement difficulties, eventually leading to death. Whereas its less severe form, Becker Muscular Dystrophy (BMD), also caused by the DMD gene mutations, shows slower patterns of progression with much later onset. This review discusses the various mutations resulting in DMD, its genetic basis, the diagnostic tools for performing a genetic diagnosis of having DMD and also advocates the necessity of having genetic therapies and employing nutraceuticals for therapy in the context of this disease. Furthermore, we have also highlighted several treatment options, such as antibacterial drugs, AON-mediated exon skipping therapy, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR-Cas9) gene-editing technology, nutraceutic.. View More»
  DOI: 10.35248/2157-7412.24.15.413

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