Andrology-Open Access
Open Access
ISSN: 2167-0250
ISSN: 2167-0250
Department of Veterinary Medical Sciences, University of Bologne, Bologna, Italy
Research Article
Concomitant Increases in Both Prostate Gland and Blood Serum VEGF Levels at the Onset of Rat Age Related Benign Hyperplasia would be Related with an
Increase in Both Processing and Secretion of Prostatic VEGF
Author(s): Trujillo-Rojas L, Fernández-Novell JM, Blanco-Prieto O, Rigau T, Rivera del Álamo MM and Rodríguez-Gil JE*
Our research team recently demonstrated that the onset of rat age-related Benign Prostatic Hyperplasia (BPH) is
concomitant with parallel increases of both prostatic and blood serum Vascular Endothelial Growth Factor (VEGF)
levels. This follow up was centered in how prostatic expression and location of VEGF modify depending on the BPH
onset was raised. To evaluate this, prostatic expression and location of both VEGF and its specific receptor (VEGF-R)
were analyzed by both Western blot and immunohistochemistry in rats with separate ages. Results indicate that
VEGF significantly (P<0.05) increased its prostate expression in BPH-affected rats, being this increase parallel with a
change in the intracellular VEGF location, which went from a per membranous situation in healthy animals to an
intracytoplasmic one in BPH-affected ones. Moreover, there was evidence of a .. View More»
DOI:
10.35248/2167-0250.22.S1.003