Andrology-Open Access
Open Access

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain

Publications

• Research Article   
  Concomitant Increases in Both Prostate Gland and Blood Serum VEGF Levels at the Onset of Rat Age Related Benign Hyperplasia would be Related with an Increase in Both Processing and Secretion of Prostatic VEGF
  Author(s): Trujillo-Rojas L, Fernández-Novell JM, Blanco-Prieto O, Rigau T, Rivera del Álamo MM and Rodríguez-Gil JE*
  
  Our research team recently demonstrated that the onset of rat age-related Benign Prostatic Hyperplasia (BPH) is concomitant with parallel increases of both prostatic and blood serum Vascular Endothelial Growth Factor (VEGF) levels. This follow up was centered in how prostatic expression and location of VEGF modify depending on the BPH onset was raised. To evaluate this, prostatic expression and location of both VEGF and its specific receptor (VEGF-R) were analyzed by both Western blot and immunohistochemistry in rats with separate ages. Results indicate that VEGF significantly (P<0.05) increased its prostate expression in BPH-affected rats, being this increase parallel with a change in the intracellular VEGF location, which went from a per membranous situation in healthy animals to an intracytoplasmic one in BPH-affected ones. Moreover, there was evidence of a .. View More»
  DOI: 10.35248/2167-0250.22.S1.003

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