Journal of Osteoporosis and Physical Activity
Open Access
ISSN: 2329-9509
ISSN: 2329-9509
Department of Orthopedics, University of Pennsylvania, Pennsylvania, USA
Research Article
Bone Remodeling Assessment in Patients with Renal Osteodystrophy Undergoing Vibrational Therapy: A MRI Finite Element Analysis Approach
Author(s): Daniel C. Kargilis, Rashad Madi*, Alexandra S. Batzdorf, Sofia M. Miguez, Jonathan Guntin, Elizabeth A. Kobe*, Felix W. Wehrli and Chamith S. Rajapakse
Introduction: Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a bone remodeling disorder resulting from impaired renal function. Patients with CKD have an increased risk of fractures, and current treatments offer limited effectiveness. Alternative interventions have been proven to be effective such as Low-Intensity Vibrational therapy (LIV) that triggers an anabolic bone response increasing the Bone Mineral Density (BMD) with no adverse effects. Our study aims to use MRI based finite element modeling to simulate bone strains in patients with Renal Osteo Dystrophy (ROD) at baseline and determine whether the results can help identify the relationship between the simulated strains and actual bone remodeling after Low-Intensity Vibration (LIV) therapy. By establishing this relationship, our study seeks to provide insight into the microarchitectural changes i.. View More»
DOI:
10.35248/2329-9509.25.13.434