Journal of Leukemia
Open Access

Department of Internal Medicine and Clinical Hematology, Ain Shams University, Cairo Governorate, Egypt

Publications

• Research Article   
  Assessment of the Early Reachability of Major Molecular Response (MMR) in Chronic Phase of CML Patients on First and Second Generation Tyrosine Kinase Inhibitors (TKI): As Regard 1st and 2nd Line of Treatment
  Author(s): Mohamed AbdAllah Shazly*, Mohamed Osman Azzazi, Rasha Magdy Mohamed Said and Amina Ahmed Mohamed Allam
  
  Background: CML treatment changed with the development of Tyrosine Kinase Inhibitors (TKIs) that interfered with the interaction between the BCR-ABL oncoprotein and Adenosine Triphosphate (ATP), blocking malignant clone proliferation. Aim: To assess early reachability of Major Molecular Response (MMR) of CML patients in chronic phase on first and second generation TKI. Patients and methods: MMR was assessed by quantitative PCR for BCR-ABL in 100 patients with newly diagnosed CML divided to three groups: First enrolled 40 patients on first generation TKI (imatinib) second enrolled 40 patients shifted from first generation (imatinib) to second generation (nilotinib) and third enrolled 20 patients on second generation (nilotinib) from the start. Patients were recruited from hematology department; Ain shams un.. View More»
  DOI: 10.35248/2329-6917.22.10.S2.005

  Abstract HTML PDF