Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Pharmacy, Federal University of Juiz de Fora, Campus Governador Valadares, Governador Valadares - MG, Brazil
Research Article
Type I and II Interferon are Associated with High Expression of the Hippo Pathway Family Members
Author(s): Bianca Sciescia, Raquel Tognon, Natalia de Souza Nunes*, Tathiane Maistro Malta, Fabiani Gai Frantz, Fabiola Attie de Castro and Maira da Costa Cacemiro
The Hippo pathway plays a regulatory role on inflammation and cell death and proliferation. Here we described a
relationship between Hippo pathway components and inflammation in healthy subjects. The plasma levels of
cytokines and chemokines were used to define their inflammatory profile and classify them as normal, high and low
producers of cytokines. Leukocytes from healthy subjects with inflammatory profile expressed the highest levels of MSTS1/MST2, SAV1, LATS1/LATS2, MOB1A/MOB1B and YAP genes. The group that overexpressed Hippo
pathway-related genes secreted more IFN-ϒ and IFN-α2... View More»
DOI:
10.35248/2155-9899.20.11.585