Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609


Queenter Oloo

Department of Biochemistry, Microbiology and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Kenya

  • Review Article   
    The Effects of Paracetamol on the Liver and Kidney Functions of a Rat Model Following Prolonged Alcohol Administration
    Author(s): Queenter Oloo*

    Objectives: Despite the potential health risks, Paracetamol is commonly misused for management of hangover among regular users of alcohol. Studies on the combined use of the two drugs are limited and controversial. The aim of this study was to evaluate the effects of the interaction of the two drugs on the biological parameters of a rat model. Methods: Animals were divided into twelve groups. The negative and positive controls received distilled water and alcohol, respectively. Alcohol was administered at 2.5, 3.5 and 4.5 g/kg orally for 4 weeks. Paracetamol was given at doses of 40 and 400 mg/kg. Half of the other groups received combined doses of the two drugs. Hematological and blood chemistry were determined using auto-analyzers while histostructure was scored under light microscopy. Results: Alc.. View More»
    DOI: 10.35248/2157-7609.21.12.256

    Abstract HTML PDF