Journal of Leukemia
Open Access
ISSN: 2329-6917
ISSN: 2329-6917
Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
Research Article
Effects of Vitamin A and D on DNA Methyltransferases 3A and 3B Expression and Neural Stem Cell Differentiation
Author(s): Pooneh Mokarram*, Parisa Alizadeh, Saeideh Saeb, Nasim Rahmani-Kukia, Marzieh Babazadeh and Morvarid Siri
Background: In Multiple Sclerosis (MS) as the demyelination happens, Oligodendrocyte Precursor Cells (OPCs)
migrate to the site of injury and start differentiating into mature oligodendrocytes to regenerate the myelin sheaths.
This OPC differentiation process can be affected by the epigenetic mechanisms which are mediated by a family of
DNA methyltransferases (DNMTs) such as DNMT3A and DNMT3B. However, Dietary factors can alter the DNMTs
expressions and even their activities. Therefore, in this study the effect of dietary factors such as vitamin A and D on
the expression of DNMT3A and DNMT3B genes was assessed during these cells.
Methods: Rat embryonic stem cells were derived from ganglionic eminence. Then, the stem cells were cultured,
differentiated and divided into five groups: control negative, control positive and three.. View More»
DOI:
10.35248/2329-6917.21.9.270