Journal of Leukemia
Open Access
ISSN: 2329-6917
ISSN: 2329-6917
Pediatric Oncology Department, National Cancer Institute, Cairo University, Children Cancer Hospital 57357, Egypt
Research Article
Efficacy of Voriconazole Prophylaxis in Pediatric Patients with Acute Myeloid Leukemia, Single Center Experience, Egypt
Author(s): Youssef Madney*, Omar Arafah, Hader Elmahalawy and Lobna Shalby
Background: Patients with hematologic malignancies are at higher risk for Invasive Fungal Infections (IFI) mainly patients with acute myeloid leukemia. Antifungal prophylaxis can help to decrease the incidence of these infections and their related complications.
Patients and methods: Prospective study compared to historical control data included 136 newly diagnosed Acute Myeloid Leukemia patients treated at the National Cancer Institute, Cairo University from 2011 to 2014. The prospective group received primary Voriconazole compared to retrospective control regarding the infectious complications and incidence of fungal infection.
Results: One hundred thirty-six (136) newly diagnosed pediatric AML patients were included in the study, 61 patients didn't receive antifungal prophylaxis (Non-prophylactic arm) while .. View More»
DOI:
10.35248/2329-6917.19.7.258