Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, Nigeria
Research Article
Effect of Ethanol Leaf Extract of Spilanthes filicaulis on Liver Indices and Selected Biochemicals on Carbon Tetrachloride Induced Hepatic Damage in Wistar Rats
Author(s): Ohwokevwo OA and Ogunka-Nnoka CU*
This study investigated the effect of ethanol leaf extract of Spilanthes filicaulis on liver indices and selected biochemicals on carbon tetrachloride induced hepatic damage in wistar rats. A total of thirty (30) rats comprising of five (5) rats per group (90-130 g), were used for the study. Groups 1-3, served as normal, negative (CCl4 induced 1 mL/kg, 1:1 i.p.) and positive (CCl4 induced and administered with silymarin 50 mg/kg) controls respectively. Groups 4-6 were the extract treated groups administered with 250 mg/Kg bw, 500 mg/Kg bw and 750 mg/Kg bw respectively for 14 days. The results of the liver marker enzymes showed a significant decrease (p<0.05) in Alanine Transaminase (ALT), Alkaline Phophatase (ALP) and γ-Glutamyl Transferase (GGT) levels in the positive control and extract treated groups, while aspartate transaminase (AST) levels.. View More»
DOI:
10.35248/2167-0412.19.8.342