Journal of Physical Chemistry & Biophysics
Open Access
ISSN: 2161-0398
ISSN: 2161-0398
Department of Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, 533001, East Godavari district, Andhra Pradesh, India
Review Article
HPLC Hyphenations in Advanced Analytical World
Author(s): Mohammed Navaziya*
Traditional analytical approaches of HPLC found to be insufficient for solving upcoming challenges
in species specificity and sensitivity analysis. Modern analytical hybrid techniques which are referred as
hyphenations have been introduced from the traditional techniques to overcome the challenges in the
analysis of components. Hyphenated approaches combine separation and detection procedures through
the use of chromatographic and spectroscopic techniques. The various hyphenations of that are developed
until now are LC-MS, LC-NMR, LC-IR, LC-DAD and it also includes multi hyphenations like LC-MS-MS,
LC-ESI-MS. These techniques show high specificity and sensitivity. Now-a-days various types of LC-MS
systems with various types of interfaces are a commercially available. The application of these hyphenations
in many sectors such as forensic science, environment, bi.. View More»
DOI:
10.35248/2161-0487-22.12.328