Journal of Pharmacological Reports
Open Access
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Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran
Research Article
The Effects of Shilajit on Serum Levels of Cytokines and Adipokines in Rats with the Non-Alcoholic Fatty Liver Disease
Author(s): Baran Ghezelbash, Nader Shahrokhi*, Mohammad Khaksari, Gholamreza Asadikaram and Sara Shirazpour
Background/Objectives: The non-alcoholic fatty liver disease is a common cause of chronic liver disease which
associated with obesity and diabetes and has a worldwide outbreak. The aim of this study cytokines and adipokines
caused by NAFLD.
Methods: Thirty-five Wistar male rats after establish fatty liver models by feeding a high fat diet (HFD, 12 weeks) were
randomly divided into five groups (n=7 rats/each group); control (standard diet), VEH (HFD+VEH), high dose
Shilajit (HFD+250 mg/kg/day Shilajit by gavage for 2 weeks), low dose Shilajit (HFD+150 mg/kg/day Shilajit by
gavage for 2 weeks), pioglitazone (HFD+10 mg/kg/day pioglitazone by gavage for 2 weeks). The serum levels of
glucose, insulin, IL-1β, IL-6, TNF- α, IL-10, adiponectin and resistin were measured after the two-weeks of
intervention.
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DOI:
10.35248/jpr.24.8.212