Laboratory of Life Sciences, Shenzhen Icybetel Biotechnology Co, Ltd, Shenzhen, China
Mini Review
Arecoline is the Causative Factor for Oral Carcinogensis? A Review of Arecoline Associated Cancer in Animal Experiments
Author(s): Jin Lu* and Ming Chu
Arecoline is a controversial composition with pharmacological activity and toxicities, which is speculated to the major cause of oral carcinogensis reported by many studies. However, there is no data or evidence in humans regarding the carcinogenicity of arecoline due to indirect exposure to it. In 2020, arecoline was classified as “possibly carcinogenic to humans” (Group 2B) on the basis of “strong” mechanistic evidence by International Agency for Research on Cancer (IARC). In fact, the inference of arecoline leading to carcinogenic processes in oral carcinogensis has not been proven by experiments in vivo. Hence? this review was aimed at evaluating the existing articles regarding the arecoline induced cancer in the animal experiments. The PubMed database of the National Library of Medicine was used to search for publications that investigated the ass.. View More»
DOI:
10.35248/JPR.22.6.132