Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
ISSN: 2165-8048
College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, P.R. China
Review Article
Current Progress in Molecular Hydrogen Medication: Protective and Therapeutic Uses of Hydrogen against Different Disease Scenarios
Author(s): Tarekegn Gebreyesus Abisso, Yao Mawulikplimi Adzavon, Pengxiang Zhao, Xujuan Zhang, Xin Zhang, Mengyu Liu, Limin Wang, Xuemei Ma* and Wang Zhen
For centuries, molecular hydrogen (H2) was supposed to be inactive and useless in the cells of mammals. Scholars reversed this notion by representing that H2 reacts with extremely reactive oxygen species (ROS) like hydroxyl radical (•OH) and peroxynitrite (ONOO-) in cells. H2 has appeared as a uniquely therapeutic and preventive agent, with its antioxidant, anti-inflammatory and anti-apoptotic properties confirmed in surplus of experimental animal models and human studies. H2 can be administered by different approaches, comprising direct inhalation in the form of hydrogen gas, oral intake of hydrogen-rich water (HRW), and injection with hydrogen-rich saline (HRS) against the majority of disease conditions. Numerous antioxidant systems are restricted and unsuccessfully picked up by organelles such as mitochondria, but H2 has t.. View More»
DOI:
10.35248/2165-8048.20.10.314