Chemotherapy: Open Access
Open Access

Department of Oncology, Guizhou Medical University and Department of Lymphoma, Affiliated Hospital of Guizhou Medical University, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China

Publications

• Research Article   
  Pharmacokinetics, Safety Profiles and Efficacy of Liposomal Mitoxantrone Hydrochloride in Patients with Relapse/Refractory Advanced Lymphoma
  Author(s): Yunfei Hu*, Weiwei Ouyang, Jing Zhang, Mengxiang Chen, Daoping Qing, Qiangxing Zeng, Ye Huang, Chunyan Hao, Rui Jia, Zhufeng Wu, Shaonan Ni and Yunhong Huang
  
  Background: Compared with conventional mitoxantrone, liposomal mitoxantrone hydrochloride (PLM60) has shown promising antineoplastic effect and better safety profiles in the previous studies, and worth a further evaluation on its pharmacokinetic profiles. Methods: In this single-center, open-label, randomized, parallel-group study, patients with histologically/cytologically confirmed relapse/refractory non-Hodgkin lymphoma (n=18) and Hodgkin lymphoma (n=6) were randomized to receive PLM60 12 mg/m2, 16 mg/m2 and 20 mg/m2 on day 1 of each 28-day cycle until the completion of 4 cycles treatment, disease progression, intolerable toxicities, or patient/investigator decision to withdraw (whichever occurred first). Blood samples were collected at prespecified timepoint and the primary endpoint was the pharmacokinetic parameters of total mitoxantrone and free mitoxantrone, the second e.. View More»
  DOI: 10.35248/2167-7700.23.11.175

  Abstract HTML PDF