Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Phase 1 Clinical Research Center, Affiliated Hospital of Guizhou Medical University, Guizhou Province Tumor Hospital, Guiyang, China
Research Article
Pharmacokinetics, Safety Profiles and Efficacy of Liposomal Mitoxantrone Hydrochloride in Patients with Relapse/Refractory Advanced Lymphoma
Author(s): Yunfei Hu*, Weiwei Ouyang, Jing Zhang, Mengxiang Chen, Daoping Qing, Qiangxing Zeng, Ye Huang, Chunyan Hao, Rui Jia, Zhufeng Wu, Shaonan Ni and Yunhong Huang
Background: Compared with conventional mitoxantrone, liposomal mitoxantrone hydrochloride (PLM60)
has shown promising antineoplastic effect and better safety profiles in the previous studies, and worth a further
evaluation on its pharmacokinetic profiles.
Methods: In this single-center, open-label, randomized, parallel-group study, patients with histologically/cytologically
confirmed relapse/refractory non-Hodgkin lymphoma (n=18) and Hodgkin lymphoma (n=6) were randomized to
receive PLM60 12 mg/m2, 16 mg/m2 and 20 mg/m2 on day 1 of each 28-day cycle until the completion of 4 cycles
treatment, disease progression, intolerable toxicities, or patient/investigator decision to withdraw (whichever occurred
first). Blood samples were collected at prespecified timepoint and the primary endpoint was the pharmacokinetic
parameters of total.. Read More»
DOI:
10.35248/2167-7700.23.11.174
