Rheumatology: Current Research
Open Access
ISSN: 2161-1149 (Printed)
ISSN: 2161-1149 (Printed)
Research Institute of Joint Diseases, Kobe, Japan
Research Article
OASL rs10774580 SNP is Associated with Herpes Zoster Infection in
Rheumatoid Arthritis
Author(s): Marowa Hashimoto*, Keiko Funahashi, Ken Tsumiyama, Yoshinori Takashima, Toshihisa Maeda, Koji Fukuda, Shinya Hayashi, Ryosuke Kuroda and Tsukasa Matsubara
Introduction: Herpes Zoster (HZ) is known as a side effect of using biologics in Rheumatoid Arthritis (RA).
Incidence of this side effect may be different depending on genetic factors because susceptibility to HZ infection
varies by race. Here, we analyzed the statistical relationships of whole genome Single Nucleotide Polymorphisms
(SNPs) with HZ infection in biologics-treated RA patients.
Materials and methods: The subjects were 321 Japanese female RA patients (including 56 herpes virus infected
patients) using biologics. The relationships of 302,814 SNPs with HZ infection were analyzed using case-control
analyses by the Chi-square test. We picked up SNPs (P<10-8) significantly associated with HZ infection. Then, the
effects of the SNPs were analyzed by using a multivariate logistic regression analysis adjusted for the a.. View More»
DOI:
10.35841/2161-1149.22.12.312