Immunogenetics: Open Access
Open Access
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Department of Immunology, Laboratory of Medical Immunology, Erasmus University Medical Centre, Rotterdam, The Netherlands
Research Article
Cumulative Incidence and Severity of COVID-19 in Patients with Immune-Mediated Diseases and the Impact of Social Distancing Measures
Author(s): Liesa van der Aa, Marijn van der Sluis, Sandra den Otter, Frank van Boven, MW van der Ent, Paul LA van Daele, Virgil ASH Dalm, Jan AM van Laar, P Martin van Hagen, Saskia Rombach and Maud Hermans*
Background: It is a matter of debate whether patients with Immune-Mediated Diseases (IMD) are at increased risk
infection with SARS-Cov-2 and a severe course of disease. The aim of this study was to evaluate the cumulative
incidence and severity of COVID-19 among patients with immune-mediated diseases and primary immunodeficiency,
taking into account the adherence to social distancing measures.
Methods: A longitudinal cohort study of outpatients of the clinical immunology department of a tertiary medical
Centre was conducted, with their household members as control population. Questionnaires regarding COVID-19,
severity of disease and adherence to social distancing measures were systematically conducted by telephone. The
cumulative incidence was calculated from the beginning of the pandemic until January 29, 2021.
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DOI:
10.35248/igoa.21.6.150