Journal of Sleep Disorders & Therapy
Open Access
ISSN: 2167-0277
ISSN: 2167-0277
Department of Informatics, Imaging and Data Sciences, School of Health Sciences, Medicine and Health, The University of Manchester, Manchester, UK
Research Article
Narcolepsy Associated Genetic Variants Associated with Impaired Cognition in A Community Dwelling Older Cohort
Author(s): Steven Jervis*, Antony Payton, Marcus Lowe, Altug Didikoglu, Arpana Verma and Kay Poulton
Objective: Studies have hypothesised that the combination of pre-existing genetic traits and specific environmental triggers determine the onset of the Narcolepsy. The most impactful genetic risk factor is the presence of Human Leukocyte Antigen (HLA) DQB1*06:02 encoded on the Major Histocompatibility Complex (MHC), however, the presence of HLA-DQB1*06:02 is not ubiquitous in all narcolepsy cases. The most poignant genetic risk factors outside the MHC are predominantly located in genes associated with the immune system. In addition to the traditional symptoms of narcolepsy, the co-morbidities can vary with a cohort of sufferers complaining of cognitive dysfunction, particularly memory and attention. These self-report are not substantiated by consistent scientific evidence whereas there is significant evidence outlining the genetic contribution underpinning variation i.. View More»
DOI:
10.35248/2167-0277.23.12.452