International Journal of Physical Medicine & Rehabilitation

International Journal of Physical Medicine & Rehabilitation
Open Access

ISSN: 2329-9096

Makoto Tominaga

Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki, Japan

  • Mini Review   
    Physiological Significance of TRPV4 Channels in Non-Myelinating Schwann cells
    Author(s): Xiaona Feng, Xuejun Song and Makoto Tominaga*

    Schwann cells (SCs) are specialized glial cells that wrap and protect axons in the peripheral nervous system (PNS). There are a variety of SCs including non-myelinating SCs such as Remak SCs, perisynaptic/ terminal SCs, repair/ Bünger SCs and nociceptive SCs that surround axons or axon terminals without forming myelin sheath. Non-myelinating SCs play important roles in proper myelin development and maintenance, repair and regeneration after injury, and nociception. A recently published work showed that transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable permeable cation channel, is exclusively expressed in non-myelinating SCs rather than myelinating SCs and plays an important role in nerve demyelination in response to injury. In this short communication, we are going to review the recent studies and discuss the possible significance of TRPV4 channels in the non-mye.. View More»
    DOI: 10.35248/2329-9096.21.9.588

    Abstract HTML PDF