Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
Short Communication
EphA2 Receptor Activation by Doxazosin as Potential Therapeutic Strategy Beneficial for Myocardial Infarction and Ischemia-Reperfusion Injury
Author(s): Kamaldeep Kaur*, Nitish Sharma, Komal Kashyap, Puja Gulati, R. K. Dhawan and Nirmal Singh
Myocardial Infarction (MI) is caused by prolonged ischemia resulting in necrosis to a portion of myocardium. Timely reperfusion to restore blood flow to ischemic myocardium is only mainstay therapy. Experimental models that mimic human Myocardial infarction include permanent closure of Left Anterior Descending coronary artery (LAD). To explore the role of EphA2 receptors and investigate the novel protective role of Doxazosin as EphA2 agonist in MI in vivo, in rats anesthetized with ketamine 80 mg/kg and xylazine 12 mg/kg i.p., intubated with endotracheal cannula using an otoscope under ventilator-assisted ventilation with extrinsic Positive End-Expiratory Pressure (PEEP), LAD ligation was performed. After LAD ligation, animals survived 4 days post-MI; biomarkers of infarction Troponin T and Troponin I and histopathological findings were performed. Doxazosin administered at low dose in.. View More»