Journal of Nanomedicine & Biotherapeutic Discovery
Open Access
ISSN: 2155-983X
ISSN: 2155-983X
Department of Medical Sciences, Dalian Medical University, Yangzhou, China
Research Article
Inhibition of Hepatocellular Carcinoma Cell Proliferation and Metastasis by Levorotatory Polylactic Acid Electrostatically Spun Nanofibers Loaded with Ibuprofen and Acid-Sensitive Adriamycin Hydrochloride Mesoporous Silica
Author(s): Yanxu Li, Weiben Ji, Zhuoheng Liu, Lai Chang, Huiyuan Hu, Kunlin Wu, Ke Wang, Chaoying Wang, Quan Zhang, Jiefeng Gao, Tao Wang* and Wei Wu
Background: Electrostatically spun nanocarrier systems are widely used in the medical field. Adriamycin (DOX), Sodium Bicarbonate (SB) and Ibuprofen (IBU) can inhibit tumor cell proliferation and metastasis, neutralize the acidic environment and inhibit inflammation, respectively. The drug carrier system using nanofibrous membranes can inhibit the proliferation and metastasis of tumor cells. Materials and methods: MSN was used to load the antitumor drug DOX and the composite fiber membrane was prepared by using SB to complete the acid sensitization and then synergistically dispersed into a PLLA electrostatic spinning solution with IBU. Transmission electron microscopy and scanning electron microscopy were used to characterize the composite fiber membrane. The CCK-8 assay and the apoptosis assay were used to verify the toxic effects of DOX, IBU and SB on normal cells and the apoptotic .. View More»