Journal of Drug Metabolism & Toxicology
Open Access

Department of Pharmacology, University of Central Florida, Orlando, USA

Publications

• Opinion Article   
  Evaluating the Sensitivity of HL-ICOs to Hepatotoxicants: Implications for In Vitro Toxicity Assessment
  Author(s): John Simpson*
  
  New developments in in vitro toxicity testing make an effort to address the demand for trustworthy human-based safety evaluation in medication development. The term "Intrahepatic Cholangiocyte Organoids" (ICOs) refers to an in vitro disease model for regenerative medicine that is developed from a donor. Here, we investigated the expression and activity of genes implicated in drug metabolism, a significant factor in druginduced toxicity, and the exposure of Hepatocyte-like ICOs (HLICOs) to well-known hepatotoxicants in order to examine the potential of HL-ICOs in in vitro toxicity testing. In terms of CYP3A4 expression, HL-ICOs' drug metabolism was equivalent to that of Preventive Health and Health services (PHHs) and HepaRGs, while other enzymes, such CYP2B6 and CYP2D6, were expres.. View More»
  DOI: 10.35248/2157-7609.23.14.289

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