Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Breast Surgery, Chinese Academy of Medical Sciences and Peking Union College, Shenzhen 518116, China
Research Article
Mitochondria-Related Gene Signature for Prognostic Prediction and Risk Stratification in Breast Cancer Patients
Author(s): Yang Wang, Ding-Yuan Wang, Ke-Na Bu, Ji-Dong Gao and Bai-Lin Zhang*
Background: As the malignant tumor with the highest incidence in the world, Breast Cancer (BC) is the number one killer of women's healthy life. Recently, tumor metabolic reprogramming has attracted extensive attention, and mitochondria play a vital role in this process as a metabolic hub. In this study, we developed a risk signature of Mitochondrial-Associated Genes (MRGs) and evaluated its ability to predict prognosis and risk stratification in BC patients.
Methods: The transcriptomic data and clinical features of BC samples were extracted from TCGA and METABRIC. We constructed an 8 MRG signature by LASSO combined with Cox regression and assessed the performance by ROC curve. Subsequently, we combined the risk scores based on the signature with clinical features to construct a nomogram model and evaluated its accuracy by clinical calib.. View More»
DOI:
10.35248/0974-276X.25.18.690