Journal of Biomedical Engineering and Medical Devices
Open Access
ISSN: 2475-7586
ISSN: 2475-7586
Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA
Research
Validation of a Novel Noxious Pressure Device for Use in fMRI Pain Studies
Author(s): Marisa DiMarzio, Michael Spinrad, Maria Hancu, Ellinor Grinde, Jamie Chang, Julia Slyer, Michael Gillogly, Julia Prusik, Julie G. Pilitsis*, Eric Fiveland and Ileana Hancu
Background: Most fMRI studies on pain perception utilized thermal stimuli due to the lack of a non-metallic reliable, reproducible mechanical stimulus. We explored 2 potential MR compatible mechanical devices and validated one that induced changes on fMRI.
Purpose: To validate a noxious mechanical stimulus MR compatible device in a healthy cohort and a chronic pain cohort. Further to ensure this device caused changes on fMRI compared to a pressure device.
Methods: Two-healthy controls underwent fMRI scans in the presence/absence of mechanical noxious stimuli using different devices. A paradigm for administering the stimuli with the most robust responses on fMRI was developed. Reproducibility of the device was confirmed in 10 chronic pain patients and age/gender-matched healthy controls. Comparisons of patient demog.. View More»
DOI:
10.35248/2475-7586.19.4.138