Drug Designing: Open Access

Drug Designing: Open Access
Open Access

ISSN: 2169-0138

+44 1223 790975

Jada Roberts

Department of Chemical and Physical Sciences, College of Science and Mathematics, St. Thomas Campus, The University of the Virgin Islands, VI-00802, United States

  • Research Article   
    Caribbean Plants as Source of Novel Inhibitors for Main Protease, NSP-15, and RNA-dependent RNA polymerase (RdRp) of SARS-Cov-2
    Author(s): Arya Duncan, Juchara Margetson, Jada Roberts, Taquanna Baron and Neelam Buxani*

    The Covid-19 pandemic with 74,299,042 confirmed cases including 1,669,982 deaths, reported worldwide by WHO (accessed 1:21 PM EST on 12/20/2020) is one of the most challenging situations the humankind is facing currently. Though some vaccines to treat this catastrophic disease have been developed on fast track, but still exploring the more potential alternative therapies is need of the hour. In search of new drug candidates to treat this pandemic, a structure based virtual screening study was carried out on the 125 compounds isolated from the native Caribbean medicinal plants like Aloe vera, Lemon grass, Moringa Olifera, and Lignum vitae, to determine their inhibitory potential against three main drug targets of SARS CoV-2; main protease (PDB ID: 6LZE), nsp 15 (PDB ID: 6WLC), and RNA-dependent RNA Polymerase (PDB ID: 7BV2) of SARS-CoV-2. The virtual screening work.. View More»
    DOI: 10.35248/2169-0138.21.10.173

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