Journal of Clinical Toxicology
Open Access

Laboratory of Environmental Bioprocesses, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3038 Sfax, Tunisia

Publications

• Research Article   
  Nonylphenol Induced Liver Metabolic Disorders and Possible Remediation by Oleuropein and Hydroxytyrosol
  Author(s): Hela Ghorbel*, Sami Sayadi, Lobna Jlail, Héla Fourati and Ines Fki
  
  Introduction: Several toxicological studies have suggested the involvement of Endocrine Disruptors (EDCs) in Nonalcoholic Fatty Liver Disease (NAFLD) and related metabolic disorders such as obesity and Type 2 Diabetes Mellitus (T2DM). Recently, nonylphenol (NP) has been identified as a potential factor in NAFLD. The purpose of this study was to investigate the progression of NP-induced disorders and the potential protective effects of the olive bioactives oleuropein (Ol) and hydroxytyrosol (Hd) on rats' liver and metabolic parameters. Materials and Methods: Four rat groups were used: A control group (C), a Nonylphenol-Treated group (NP), a group treated with Nonylphenol and Oleuropein (NP+Ol), and a group treated with Nonylphenol and Hydroxytyrosol (NP+Hd). Various techniques were employed to assess chemical, hormonal, and histomorphometric changes. Serum nonylphenol and.. View More»
  

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