Journal of Molecular Imaging & Dynamics

Journal of Molecular Imaging & Dynamics
Open Access

ISSN: 2155-9937

Huta B,

Department of Chemistry, Connecticut College, New London,, USA

  • Perspective   
    Migration of leukocytes is controlled by actin flow direction
    Author(s): Huta B,*

    The integrin lymphocyte function-associated antigen-1 (LFA-1, L2) is involved in a variety of sticky contacts, including antigen recognition, vascular emigration, and leukocyte movement within tissues. The extended-open conformation of integrin ectodomains binds ligand with 1,000-fold higher affinity than the bent-closed and extended-closed conformations. The binding of LFA-1 to ICAM ligands by the I domain in the integrin head is conveyed to the actin cytoskeleton through the -subunit leg, transmembrane, and cytoplasmic domains via adaptors like talins and kindlins that bind particular locations in the -subunit cytoplasmic domain. Measurements of traction force on substrates, as well as more detailed measurements of force within ligands and cytoskeletal components, have suggested that integrins transmit force between extracellular ligands and the actin cytoskeleton, as discussed. In .. View More»

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