Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
ISSN: 2157-7609
Department of Bioengineering, University of California, San Francisco, USA
Commentary
Reproducing Tests: Recommendations for Designs, Statistical Analysis, and Execution of Toxicological Investigations
Author(s): Giacomini Zur*
The challenge of reproducing tests has received a lot of attention.
Problems with replication arise for a range of causes ranging
from experimental design to laboratory mistakes to inadequate
statistical analysis. Here, we go through a number of
recommendations for the design, statistical analysis, and
execution of toxicological investigations. In general, hypothesisdriven
trials with sufficient sample sizes, randomization, and
blind data collecting methods can increase replication. Both
publicly and privately within the scientific community, science is
going through a kind of crisis of faith. Some high-profile cases of
fraud have garnered public attention, including the debunked
Stimulus-Triggered Acquisition of Pluripotency (STAP) method
for STEM cells. The practicing scientist sees retractions of
articles much too frequently because of shady data and methods.
Although it is regrett.. View More»
DOI:
10.35248/2157-7609.23.14.287