Journal of Clinical and Cellular Immunology
Open Access

Department of System of Immunology, University of Würzburg, Germany

Publications

• Short Communication   
  A Brief Note on Tissue-Resident Memory Cells
  Author(s): Georg Gasteiger*
  
  Tissue-resident memory T (TRM) cells provide as a first line of defense against infections that enter through barrier locations. TRM cells in the lungs protect against infections, although they decline faster than TRM cells in other tissues. Because there isn't a stable TRM population in the lung parenchyma, infections with pathogens like influenza and respiratory syncytial virus (RSV) can reoccur throughout life. Intranasal (IN) vaccination with a murine cytomegalovirus (MCMV) vector expressing the RSV M protein (MCMV-M) has been demonstrated to produce large numbers of CD8+ TRM cells that accumulate over time and mediate early viral clearance. We evaluated the inflationary CD8+ T cell population generated by MCMV-M vaccination with a traditional CD8+ T cell population and further findings. Vaccination with MCMV-M2 resulted in a f.. View More»
  DOI: 10.35248/2155-9899.22.13.653

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