Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964

+44 1300 500008

Gaurav Gupta

Vaccine Research and Development Division, Zydus Cadila Healthcare Limited, Ahmedabad, India

  • Short Communication   
    Measles as a Vector for the Malaria Vaccine Development
    Author(s): Narayana Penta*, Gaurav Gupta and Reinhard Glueck

    Classical viral vectors have been successfully used to deliver Malaria, HPV antigens. Emerging viral vector technologies such as Measles virus (MV) are useful for vaccine development. Studies in animal models suggest that each viral vector is unique in its ability to induce humoral and cellular responses. Measles virus is a member of Mononegavirales thus the genomic RNA is not translated either in vivo or in vitro. MV replicates exclusively in the cytoplasm, ruling out the possibility of integration into host DNA. Live attenuated Measles (MeV) are thus inducing long lived immunity after a single immunization dose. MeV vector allows insertion and stable expression over multiple replications round of various genes from different genome positions, allowing comparable immunity against MeV proteins and vectored antigens. Hence in the present study we .. View More»
    DOI: 10.35248/1948-5964.21.13.212

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