Journal of Pharmaceutical Care & Health Systems
Open Access

Department of Medical Sciences, Pontifical Argentina Catholic University, 1600 Alicia Moreau de Justo Avenue-Buenos Aires (1007), Argentina

Publications

• Research Article   
  Pharmacokinetic Parameters and Tissular Biodistribution of 1,3 ?-Glucans from Maitake Pro4x in Balbc Mice
  Author(s): Diego Maximo Aguilera-Braico and Gabriela Andrea Balogh*
  
  This study aimed to analyze the pharmacokinetic parameters of 1,3-beta-glucans from Maitake Pro4X in BALBc mice through oral and Intra Venous (IV) administration. The objectives were to determine the following parameters: Tmax, Cmax, t1/2, ta1/2, Ke, Ka, Clearance, Vd, Cp0, and AUC. Additionally, the tissue distribution of 1,3-beta-glucans after oral and IV administration of Maitake Pro4X was examined to identify the organs involved in absorption, elimination, and distribution. The results comparison indicated that certain elimination constants were similar in both administration routes (ke3 IV and ke2 oral). Both routes showed a Tmax of 10 hours. The elimination t1/2 was comparable for both routes (12.93 hours for oral and 12.81 hours for IV). Total systemic clearance values were also similar. However, the IV route exhibited a higher volume of distribution but lower AUC Cp vs. time. .. View More»
  DOI: 10.35248/2376-0419.23.10.301

  Abstract HTML PDF