Journal of Depression and Anxiety
Open Access

Department of Physiology, School of Laboratory Medicine and Medical Sciences, University of Kwa-Zulu Natal, Durban 4001, South Africa

Publications

• Research Article   
  Beyond Psychopathology: Examining the Complex Interactions of Early Life Stress, Schizophrenia, and Neuro-Inflammation on Cognitive and Motor Functioning
  Author(s): Fredrick Otieno Oginga* and Thabisile Mpofana
  
  Background: The brain and the immune system are not fully formed at birth, but rather continue to mature in response to the postnatal environment. The two-way interaction between the brain and the immune system makes it possible for childhood psychosocial stressors Early Life Stress (ELS) and Parental Schizophrenia (PSZ) to affect immune system development, which in turn can impact brain development and its long-term functioning. Objective: The present study aimed to explore the complex multifaceted interactions between early-life stress, Schizophrenia (SZ), and neuro-inflammation, and their collective effect on social interaction, locomotor function and spatial memory. Methods: Male and female Sprague-Dawley rat pups were randomly assigned to eight groups: Control, ELS, schizophrenia, and ELS+schizophrenia. ELS wa.. View More»
  DOI: 10.35248/2167-1044.25.14.560

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