Anatomy & Physiology: Current Research
Open Access
ISSN: 2161-0940
ISSN: 2161-0940
Department of Anatomy, Nnamdi Azikiwe University, Anambra State, Nigeria
Research Article
Novel Potential of Vitamin C and E on the Myelin, Oligodendrocyte and Inflammatory Markers of Rohypnol Exposed Amygdala in Rats
Author(s): Ezejindu Damian Nnabuihe, Princewill Sopuluchukwu Udodi, Joshua Izuchukwu Abugu*, Benedict Kosisochukwu Ukwandu, Enemuo Ijeoma, Christian Emeka Okafor, Agulanna Ambrose Echefulachi, Ifeanacho Ezetaonu Abireh, Augustine U Agu, Augustus Uchenna Ugwu and Okara Andy-Davis chidi
Rohypnol, scientifically known as flunitrazepam, is a potent benzodiazepine medication primarily prescribed for the treatment of severe insomnia and as a pre-anesthetic medication. However, its reputation has been tarnished by its misuse as a recreational drug and its association with drug-facilitated crimes, particularly sexual assault. However, its potent sedative effects can lead to memory impairment, loss of motor coordination and respiratory depression, especially when combined with alcohol or other central nervous system depressants. This study aims to investigate and establish mechanism and novel potential of vitamin C and E on the myelin, oligodendrocytes and inflammatory markers of rohypnol exposed amygdala. Twenty-five male adult wistar rats were divided into five groups: The control group was exposed to normal atmospheric air, 1 mg/kg of rohypnol, 1 mg/kg of rohypnol+100 mg.. View More»