Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Department of Dermatology, Beni-Suef General Hospital, Ministry of Health, Egypt
Research Article
Expression of Long Non-coding RNA in Psoriasis
Author(s): Abd-El Aziz El-Rifaie, Rehab Mohamed Naguib*, Laila Ahmed Rashed and Esraa Mohamed Rasheed
Background: Psoriasis is a chronic hyper proliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Long non coding RNA (lncRNAs) act as a key regulator for the inflammatory gene expression by collaborating with the transcription factors. Aim: Detection of the expression of long non coding RNA in psoriatic skin of diseased patients as compared to normal control persons to investigate the possible role of long non coding RNA in the psoriasis pathogenesis Subjects and methods: The present study included 30 psoriatic patients and 30 age, gender-matched healthy controls. 4 mm punch skin biopsy was taken from patients (psoriatic lesion) & control and it was kept in lysis solution for the stability of the studied parameters and was kept frozen at -80°C till analysis of long non coding RNA by qRT PCR. Res.. View More»