Immunome Research
Open Access

Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Italy

Publications

• Research   
  SARS-CoV-2 and Autoimmunity: From Myocarditis to Arrhythmia and Cardiac Death
  Author(s): Darja Kanduc*
  
  Background: Clinical attention has focused recently on an unexplained insurgence of Cardiovascular Diseases (CVDs) in concomitance with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Here, this study aimed at defining the possible role of autoimmune cross-reactivity and immunologic memory as mechanisms that might link the viral infection to CVDs. Methods: Human proteins that, when altered, associate with CVDs were searched for pentapeptide immune determinants that are shared with SARS-CoV-2 spike glycoprotein (gp) and also recur in common pathogens to which the general population is frequently exposed. Results: Comparative sequence analyses show that: 1) a high level of peptide sharing exists between SARS-CoV-2 spike gp and human proteins related to CVDs; 2) the shared peptides are endowed with an immunolog.. View More»
  

  Abstract PDF