Journal of Hepatology and Gastrointestinal disorders
Open Access
ISSN: 2475-3181
ISSN: 2475-3181
Department of Critical Care Medicine, Sichuan University, Chengdu, China
Research Article
Integrated Spatial Metabolomics Profiling of Acute Pancreatitis and Pancreatic Cancer
Author(s): Shan Yang, Xia Li, Manjiangcuo Wang, Dan Du, Qianlun Pu, Na Jiang, JuQin Yang, Liuyang Cui, Huiming Lu and Chenggong Hu*
Pancreatitis and Pancreatic Cancer (PC) are the two most lethal disease branches among severe pancreatic diseases. PC may be diagnosed with pancreatitis of similar the pathological features, which may interfere with the appropriate assessment of early PC and postpone the time of diagnosis and Acute Pancreatitis (AP) is also an important risk factor for the development of PC. The spatial metabolomics based on mass spectrometry imaging is a powerful method for revealing disease-related metabolic pathways and classifying biomarkers in complex biological samples. However, there is no spatial metabolomics research report on AP and PC at the same time. This study reports the simultaneous spatial metabolomics analysis of AP and PC based on AFADESI-MSI combined with machine learning and screened metabolites such as amino acids and phospholipids related to the disease, visualized differential .. View More»